Causes & Results of Thrombosis

Causes & Results of Thrombosis

A gene mutation increases the risk of developing thrombosis by 800% - order TromboGen® test today and find out if you are also at risk.

Thrombosis is a result of mutations in gene(s) and outside factors

The genetic predisposition for thrombosis

Thrombosis is commonly a result of a mutation in gene(s) which disrupts the balance in the formation and dissolution of blood clots or increase the level of homocysteine in the blood. These are cases where the body produces a larger amount of substances causing blood coagulation. Thrombosis arises particularly from inherited genetic factors when a mutated gene or genes (compound heterozygous) is passed on to you from one parent (heterozygous) or both parents (homozygous). You may also acquire thrombophilia later in life due to changes in the clotting mechanism in your body. 

The outside factors 

A person prone to blood clots may not be affected by thrombosis for many years, or at any point in their life, but under certain circumstances (outside factors), e.g. hormonal contraception or being bedridden, the already disrupted balance may be further aggravated and may result in the manifestation of thrombosis. The outside factors contributing to the occurrence of thrombosis are as follows:-

  • smoking
  • surgery (the average PE occurs three weeks after surgery when the patient is already at home from the hospital, so doctors do not even recognise that the condition exists!)
  • venous insufficiency and varicose veins of the lower limbs
  • hormonal contraceptive use
  • hormone replacement therapy
  • limitation of mobility due to longer bed confinement or air travel
  • decreased hydration of the body
  • cancer (tumours form substances that increase blood clotting)
  • obesity
  • antiphospholipid syndrome
  • pregnancy (One in every 1,000 women will develop thrombosis during pregnancy)
  • childbirth
  • postnatal period
  • injury that reduces blood flow to parts of your body (often occurring during sport)
  • a history of heart attack, stroke, thromboembolism, or congestive heart failure

VTE is often difficult to diagnose, and may be confused with less serious conditions. Most adults undertaking surgery are at risk of developing a DVT without preventative treatment. A DVT doesn't always have obvious symptoms, but given the high percentage of potentially preventable deaths from VTE cases in UK hospitals, it's important to view every patient as a potential VTE candidate.

If you have the mutated genes, you may experience the following:-

Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) Occurrence

  • Up to 50x higher chance of developing DVT and PE
  • An increase in the chance of thrombosis recurrence
  • An increase in the chance of developing DVT by 50% if combined with the usage of birth control pills
  • An increase in the chance of developing DVT by up to 50% if combined with hormone replacement therapy
  • An increase in the chance of DVT occurrence during pregnancy by up to 100%

Pregnancy Complications and Childbirth Difficulties

  • Spontaneous abortions in the second trimester
  • Growth retardation of the foetus
  • Abruption placentae
  • Preeclampsia
  • Premature birth
  • Still birth
  • Fissure difficulties of the foetus, particularly of the spine and central nervous system
  • Decreasing viability of the foetus

Cardiovascular Diseases

  • Atherosclerosis
  • Heart attacks
  • Stroke and cardiac infarction at a younger age

Neurologic Diseases

  • Depressions
  • Schizophrenia